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鹽酸多柔比星 | 鹽酸阿霉素

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Doxorubicin(Adriamycin) Hydrochloride | Doxorubicin HCl

產(chǎn)品編號：CL1004 CAS No.：25316-40-9 MDLNo： 分子式：C27H29NO11.HCl 分子量： 579.98
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
100 mg In-stock ￥260.00 登錄后可見
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500 mg In-stock ￥750.00 登錄后可見
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1 g In-stock ￥1260.00 登錄后可見
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基本信息
英文名稱 Doxorubicin(Adriamycin) Hydrochloride | Doxorubicin HCl
中文名稱鹽酸多柔比星 | 鹽酸阿霉素
CAS號25316-40-9
分子式C27H29NO11.HCl
分子量 579.98
外觀Orange red powder
儲存條件Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
產(chǎn)品詳情

Doxorubicin is an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.

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