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首頁(yè) > 產(chǎn)品目錄 > 信號(hào)通路 > Endocrinology & Hormones > Estrogen/progestogen Receptor > (Z)-4-(1-[4-(二甲基氨基乙氧基)苯基]-2-苯基-1-丁烯)苯酚/4-羥基他莫昔芬

(Z)-4-(1-[4-(二甲基氨基乙氧基)苯基]-2-苯基-1-丁烯)苯酚/4-羥基他莫昔芬

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4-Hydroxytamoxifen | (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen;(Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol

產(chǎn)品編號(hào):CL1009 CAS No.:68047-06-3 MDLNo: 分子式:C26H29NO2 分子量:387.52
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5 mg In-stock ¥300.00 登錄后可見(jiàn)
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10 mg In-stock ¥550.00 登錄后可見(jiàn)
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25 mg In-stock ¥1050.00 登錄后可見(jiàn)
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50 mg In-stock ¥2000.00 登錄后可見(jiàn)
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基本信息
英文名稱 4-Hydroxytamoxifen | (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen;(Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol
中文名稱(Z)-4-(1-[4-(二甲基氨基乙氧基)苯基]-2-苯基-1-丁烯)苯酚/4-羥基他莫昔芬
CAS號(hào)68047-06-3
分子式C26H29NO2
分子量387.52
外觀White to off-white powder
儲(chǔ)存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen. It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 μM, respectively). It also stimulates LC3 lipidation and the formation of autophagic vesicles in MCF-7 cells in a superoxide-dependent manner. 

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