英文名稱 | LY294002 | NSC 697286 | SF 1101 |
---|---|
中文名稱 | LY294002 | NSC 697286 | SF 1101 |
CAS號 | 154447-36-6 |
分子式 | C19H17NO3 |
分子量 | 307.34 |
外觀 | White to yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | LY294002 | NSC 697286 | SF 1101 |
---|---|
中文名稱 | LY294002 | NSC 697286 | SF 1101 |
CAS號 | 154447-36-6 |
分子式 | C19H17NO3 |
分子量 | 307.34 |
外觀 | White to yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
LY294002, a morpholine-containing compound designed based on the flavonoid quercetin, is a potent and cell-permeable PI3K inhibitor, inhibiting PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM in cell-free assays, respectively. Additionally, it inhibits BET (for example, BRD2, BRD3, and BRD4). It is more stable in solutions than the PI3K inhibitor Wortmannin. By acting on the ATP binding site of the catalytic subunit of PI3K, LY294002 is selective against p110α, p110β, p110γ and p110δ.
Exploring the specificity of the PI3K family inhibitor LY294002.
Biochem J. 2007 May 15;404(1):15-21.
Evidence for functional redundancy of class IA PI3K isoforms.
PMID: 17362206 PMCID: PMC1896275 DOI: 10.1042/BJ20070003
Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond.
PMID: 23386830 PMCID: PMC3560216 DOI: 10.3389/fphar.2013.00005
PMID: 30456785 DOI: 10.1111/and.13196