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瓦他拉尼二鹽酸鹽

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Vatalanib Dihydrochloride | Vatalanib 2HCl

產(chǎn)品編號：CL1906 CAS No.：212141-51-0 MDLNo： 分子式：C20H17Cl3N4 分子量：419.73
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
20 mg In-stock ￥408.00 登錄后可見
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50 mg In-stock ￥472.00 登錄后可見
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100 mg In-stock ￥678.00 登錄后可見
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基本信息
英文名稱 Vatalanib Dihydrochloride | Vatalanib 2HCl
中文名稱瓦他拉尼二鹽酸鹽
CAS號212141-51-0
分子式C20H17Cl3N4
分子量419.73
外觀Off-white to pink powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Vatalanib (PTK787 or ZK-222584, cpg-79787 2HCl) 2HCl is a novel, potent and orally bioavailable inhibitor of VEGFR2/KDR with potential anticancer activity. In a cell-free experiment, it inhibits VEGFR2/KDR with an IC50 of 37 nM, is less effective against VEGFR1/Flt-1, and is 18-fold more potent against VEGFR3/Flt-4. With strong anti-proliferative activity in vitro and strong antitumor efficaciousness in vivo, it is an anilinophthalazine analog. The protein kinase domains of VEGFR 1 and 2 are bound by vatalanib, which then inhibits them. The PDGF receptor, c-Kit, and c-Fms are among the related receptor tyrosine kinases that this agent binds to and inhibits.

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