英文名稱 | Neratinib (HKI-272) |
---|---|
中文名稱 | 來那替尼 |
CAS號(hào) | 698387-09-6 |
分子式 | C30H29ClN6O3 |
分子量 | 557.04 |
外觀 | Pale yellow to white solid |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Neratinib (HKI-272) |
---|---|
中文名稱 | 來那替尼 |
CAS號(hào) | 698387-09-6 |
分子式 | C30H29ClN6O3 |
分子量 | 557.04 |
外觀 | Pale yellow to white solid |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Neratinib is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.