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奎扎替尼

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Quizartinib (AC220)

產(chǎn)品編號:CL2519 CAS No.:950769-58-1 MDLNo: 分子式:C29H32N6O4S 分子量:560.67
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
5 mg 3-5days ¥450.00 登錄后可見
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10 mg 3-5days ¥650.00 登錄后可見
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25 mg 3-5days ¥950.00 登錄后可見
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基本信息
英文名稱 Quizartinib (AC220)
中文名稱奎扎替尼
CAS號950769-58-1
分子式C29H32N6O4S
分子量560.67
外觀White to off-white powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Quizartinib (formerly also know as AC-220; AC-010220, Vanflyta) is a novel, potent, 2nd-generation, and orally bioavailable FLT3 tyrosine kinase inhibitor for Flt3 (ITD/WT) with potential anticancer activity.With IC50s of 1.1 nM and 4.2 nM, respectively, it inhibits FLT3 in MV4-11 and RS4EL11 cells. With respect to KIT, PDGFRα, PDGFRβ, RET, and CSF-1R, it demonstrates a ten-fold greater selectivity. Currently, Daiichi Sankyo is developing quizartinib to treat acute myeloid leukemia. Quizartinib (Vanflyta) was approved in 2023 by FDA for treating AML.

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